Mutations in TTN can cause several different neuromuscular diseases, such as tibial muscular dystrophy and cardiomyopathies, in both recessive and dominant inheritance modes (MIM IDs dilated cardiomyopathy #604145, familial hypertrophic cardiomyopathy #613765, limb-girdle muscular dystrophy type 2J #608807, proximal myopathy #603689, Salih myopathy #611705, and tibial muscular dystrophy #600334) [8,9,10,11,12]. Here, TTN is linked to tibial muscular dystrophy.