By performing unbiased proteomic profiling on immortalized lymphoblastoid cells derived from an SPTLC1-patient with juvenile-onset of ALS without brain abnormalities and normal cognitive function, we identified a set of proteins which might contribute to manifestation of certain symptoms of SPTLC1-pathology upon an individual expression level. The gene discussed is SPTLC1; the disease is amyotrophic lateral sclerosis.