HIF1A and dilated cardiomyopathy: Results indicated that the enriched pathways fell into four broad groups: (1) immune (in purple), including Th1 and Th2 cell differentiation, T cell receptor signaling, Toll-like receptor signaling, leukocyte transendothelial migration, and inflammatory mediator regulation of TRP channels; (2) myocardiopathy (in blue), including vascular smooth muscle contraction, dilated cardiomyopathy and adrenergic signaling in cardiomyocytes); (3) hematopoiesis (in red), including Platelet activation; and (4) hypoxia response (in green), including HIF-1 signaling (Figure 1a).