PFN1 and asthma: Thirteen of these overlapping DEGs have been linked to asthma, including eight upregulated genes (Il33, Hmgb1, Ager, Chia1, Ifitm3, Igfbp7, Pfn1, Retnla) and five downregulated genes (Atf3, Btg2, Klf6, Neat1, and Sec14l3) (Figure 4A,B and Figure S3(B1–B12)).