HMGB1 and asthma: Several asthma-related genes were identified: detoxification enzymes (Cyp2a5 [45], Gsto1 [46], Gstp1 [47], Gstm1 [48], and Aldh1a1 [49]) were downregulated while Hmgb1 (alarmin) [50,51] was upregulated (Figure 4C, Tables S5 and S6).