The in vitro experiments confirmed that HBV downregulated hsa-miR-101-3p expression by inhibiting its promoter activity, which resulted in the upregulation of Rap1b, and the downregulation of hsa-miR-101-3p or upregulation of Rap1b promoted the proliferation and migration of HCC cells [43]. This evidence concerns the gene RAP1B and hepatocellular carcinoma.