CDKN2A and nonpapillary renal cell carcinoma: In GEO datasets, CDKN2A showed a significantly higher expression in ccRCC tissues (GSE40435: log2(fold change) = 0.23, p = 3.76 × 10−19; GSE53757: log2(fold change) = 2.05, p = 5.02 × 10−27, Supplementary Table S1) while DLAT, FDX1 and LIAS were significantly downregulated in their expression levels in ccRCC tissues (Figure 5A,B).