The down-regulation of miR-205-5p decreased the gemcitabine susceptibility of breast cancer cells through ERp29 up-regulation [29]; miR-205-5p contributed to the resistance to paclitaxel and the development of endometrial cancer via down-regulating FOXO1 [30]; miR-205-5p/PTK7 axis participates in the growth, metastasis, and aggressionof colonic and rectal cancer cells [31]. Here, PTK7 is linked to rectal cancer.