Statistical analysis of LEP and INSIG2 in the group of schizophrenia patients revealed a significant association of genotypes and alleles of the rs3828942 of LEP gene (chi2 = 7.665, p = 0.022; chi2 = 5.136, p = 0.023) (Table 2) and the genotypes of the rs17047718 of INSIG2 gene (chi2 = 7.7, p = 0.021) with MetS (Table 3). This evidence concerns the gene INSIG2 and schizophrenia.