Moreover, under hypoxic conditions, the upregulation of TrkAIII occurs, which provides tumor progression and metastasis promotion; it plays an oncogenic role in NB and indicates relevance to the NB-regulated tumor-promoting switch by generating an angiogenic, stress-resistant, and tumorigenic NB phenotype via IP/Akt signaling [71,72,73,74,75]. The gene discussed is AKT1; the disease is neuroblastoma.