To date, in addition to blood-related cancers, USP10 also plays oncogenic roles in many solid tumors including hepatocellular carcinoma (HCC) [46], colon cancer [68,84], renal-cell carcinoma (RCC) [27], non-small-cell lung cancer (NSCLC)[27], prostate cancer (PCa) [87,88], esophageal cancer [87,88], breast cancer [75,89], and melanoma [87,88]. The gene discussed is USP10; the disease is hereditary clear cell renal cell carcinoma.