In immune system diseases, such as asthma and systemic sclerosis, USP10 influences inflammatory responses by inhibiting T-box transcription factor (T-bet) ubiquitination and stabilizing its expression, and thus, it has also been found that quercetin, an inhibitor of USP10, alleviates asthma via enhancing the ubiquitination and promoting the degradation of T-bet [14]. The gene discussed is TBXT; the disease is immune system disorder.