Growing evidence has shown that USP10 plays important tumor-suppressor roles in different cancers, such as colorectal cancer, non-small-cell lung cancer, small intestinal adenocarcinoma, epithelial ovarian cancer, colorectal cancer, renal-cell carcinoma, breast cancer, and gastric cancer [99,100,101]. Here, USP10 is linked to hereditary clear cell renal cell carcinoma.