Feng et al. [17] found that urethral injury leads to the activation of the TGF-β1 signal, which further promotes the proliferation, activation, and migration of urethral fibroblasts reduces the secretion of IP10 by fibroblasts, inhibits the IP10/CXCR3 signaling pathway, accelerates the pathological process of urethral fibrosis, and ultimately leads to urethral stricture. The gene discussed is CXCL10; the disease is urinary system disorder.