For example, the IDH1 mutations we detected by NGS in Idylla-detectable BRAF or KRAS mutation positive CRC specimens (Tables S6 and S7) are associated with mucinous or signet ring cell adenocarcinoma, thus providing molecular support for the correct diagnosis that would not be possible from the Idylla results [49]. This evidence concerns the gene BRAF and signet ring cell carcinoma.