APC and non-small cell lung carcinoma: For instance, methylation levels of promoter regions of cyclin-dependent kinase inhibitor 2A (CDKN2A), cadherin 13 (CDH13), ras association domain family member 1 (RASSF1A), and adenomatous polyposis coli (APC) are associated with the early recurrence of stage I non-small cell lung cancer (NSCLC) after curative surgery [176].