RRM2 and hepatocellular carcinoma: Finally, we found 12 upregulated genes (BUB1, BUB1B, CDC20, CDCA8, KIF2C, KIF11, TOP2A, TTK, CDC6, CDK1, RRM2, and UBE2C) were associated with a poor prognosis of HCC when they are overexpressed (Figure 5).