A distal critical region in 12q21.33, encompassing the four Decorin (DCN, OMIM *125255), Keratocan (KERA, OMIM *603288), Lumican (LUM, OMIM *600616) and Epiphycan (EPYC, OMIM *601657) genes, defines the contiguous gene deletion syndrome PACD (posterior amorphous corneal dystrophy, OMIM #612868), for which DCN appears as the most relevant gene according to haploinsufficiency prediction (Supplementary Table S1) [10]. Here, EPYC is linked to posterior amorphous corneal dystrophy.