CD8A and type 1 diabetes mellitus: However, other analyses demonstrated that CD8(+) and CD4(+) T-cell reactivity to islet-specific antigens in diabetic patients was more prevalent in T1D subjects than in healthy donors, and CD4(+) T-cell autoreactivity appears to be present in both T1D and T2D, while autoreactive CD8(+) T-cells are unique to T1D [39].