Some authors have mentioned the association between T2D and histocompatibility antigens, and most of the HLA haplotypes have been associated with a high risk to develop both insulin and non-insulin-dependent diabetes [22,23,24]; most reports have also associated with MHC-II [13,14,15,25,26,27,28,29,30,31]. This evidence concerns the gene INS and type 2 diabetes mellitus.