In this study, we aimed to further elucidate the role of inflammation and oxidative stress in the pathogenesis of ALS by genotyping ALS patients and controls for common genetic polymorphisms in genes involved in antioxidant (SOD2, GPX, and CAT) and inflammatory pathways (IL1B, TNF, IL6, MIR146A). This evidence concerns the gene TNF and amyotrophic lateral sclerosis.