This study investigated GLUT1 and GLUT3 gene expression and HIF-1α protein expression in PMSCs derived from MC twins with sIUGR and cultured under normal oxygen and hypoxic conditions; changes in placental glucose transport under hypoxia in growth-restricted and AGA-growth fetuses were evaluated to determine whether IUGR placentas exhibit lower hypoxia-induced upregulation of GLUT gene expression. This evidence concerns the gene SLC2A1 and fetal growth restriction.