On the other hand, the 125 LLI-lost c-CCM-related genes were clustered into ribosome, tumorigenesis and immune system-associated pathways, including ribosome (hsa03010), ribosome biogenesis (hsa03008), viral carcinogenesis (hsa05203), transcriptional misregulation in cancer (hsa05202), IL-17 signaling pathway (hsa04657) and NOD-like receptor signaling pathway (hsa04621) (Figure 4B and Table S6), indicating that at least some of the circRNAs in the lost c-CCMs may be related to translation regulation and immune response. The gene discussed is IL17A; the disease is cancer.