Another study using next-generation whole transcriptome sequencing as a discovery tool identified a cis-SAGe chimera TMED6-COG8, a potential diagnostic marker, in TFE3 translocation renal cell carcinoma (tRCC), since its expression was significantly higher in TFE3 tRCCs compared to clear-cell RCCs and papillary RCC [86]. This evidence concerns the gene TFE3 and hereditary clear cell renal cell carcinoma.