Rubino et al. [142] performed a meta-analysis comprising 2961 migraineurs (2170 patients with MA and 791 patients with MO), linking the MTHFR C677T polymorphism to migraine, and found evidence that MTHFR was associated with MA only (OR = 1.30, 95% CI [1.06–1.58]). The gene discussed is MTHFR; the disease is migraine disorder.