In a recent GWAS studies of 102,084 migraineurs [225] and 74,124 T2D patients [226], the SNP rs1472662 [nearest coding gene MACF1 (microtubule actin crosslinking factor 1)] and rs42854 (nearest coding gene ANKDD1B (ankyrin repeat and death domain containing 1B)] were found to be significantly associated (p < 5 × 10−8) with migraine and T2D and four SNPs were associated with migraine and T2D at genome-wide suggestive level. This evidence concerns the gene MACF1 and migraine disorder.