Although a study of 47 Caucasians [166] with T2D reported no substantial difference in the allelic frequency of Pvull polymorphism of ESR1 between type 2 diabetic and control groups, there was, however, a significant association between Pvull polymorphisms and T2D in African-Americans, European-Americans [166,167], Hungarians [211] and Egyptian women [212]. This evidence concerns the gene ESR1 and type 2 diabetes mellitus.