Two genome-wide significant loci associated with migraine (rs1472662 near MACF1 and rs42854 near ANKDD1B) have also been associated with T2D at the genome-wide significant level, and two genes (MACF1 and THADA) have been associated with both migraine and T2D at the gene-based genome-wide significant level. The gene discussed is MACF1; the disease is type 2 diabetes mellitus.