ADLTE onset is associated with mutations in the LGI1, RELN, or MICAL1 genes that code for the Leucine-rich Glioma-Inactivated 1 (LGI1), Reelin, and the molecule interacting with CasL 1 (MICAL1) proteins, respectively [3,4,5]. The gene discussed is MICAL1; the disease is autosomal dominant epilepsy with auditory features.