BAFF is a cytokine of the tumour necrosis factor (TNF) family, and some evidence suggests it could activate the tumour necrosis receptor-associated factor 6 (TRAF6)/NF-kB pathway in glomerular mesangial cells, consequently contributing to the pathogenesis of IgA nephropathy [22]. The gene discussed is TNFSF13B; the disease is IgA glomerulonephritis.