In general, the underlying genetic defects of familial hypercholesterolemia are caused by the LDLR gene in 90%, by the APOB gene in 5–10%, and the PCSK9 gene in less than 1% of cases, and origination from the LDLRAP1 gene is very rare [2,6]. The gene discussed is PCSK9; the disease is familial hypercholesterolemia.