LDLRAP1 and autosomal dominant disease: In general, FH is an autosomal dominant disease caused by mutations in the genes coding for LDL-receptor (LDLR), apolipoprotein B (APOB) or proprotein convertase subtilisin kexin type 9 (PCSK9), or autosomal recessive related to the low-density lipoprotein receptor adaptor protein 1 (LDLRAP1) [2,5,6].