It was shown that NLRP3 signalling is upregulated in COVID-19 lungs, together with many ‘DAMPs’ such as metabolic dysregulation and ROS that are triggered by SARS-CoV-2 and can lead to NLRP3-inflammasome-mediated pyroptosis leading to a cytokine storm[91] . The gene discussed is NLRP3; the disease is COVID-19.