SHPRH and glioblastoma: Specifically, Zhang et al. demonstrated that the circular RNA transcribed by the SNF2 histone linker PHD RING helicase (SHPRH) gene can be translated into a 17 kDa SHPRH-146aa protein that protects the full-length SHPRH from degradation by the ubiquitin proteasome, leading to inhibition of cell proliferation and tumorigenicity in glioblastoma [76].