The same model of action was demonstrated for several other circRNAs, for example: circ-SRY (for sex-determining region Y) sponges miR-138 in mice testes [69]; circ-ITCH, derived from several exons of itchy E3 ubiquitin protein ligase (ITCH), sponges miR-7, miR-17 and miR-214, in esophageal squamous cell carcinoma [71], and miR-214 also in osteogenic differentiation [72]. The gene discussed is ITCH; the disease is esophageal squamous cell carcinoma.