Ligand-dependent activation of AhR can promote the differentiation of the immunosuppressive regulatory T cells (FoxP3+) [19], as well as type 1 regulatory T cell-like cells (IL-10+Tr1) [20], which dampens intestinal inflammation by producing IL-10 and CD-39; however, dysregulation of the AhR pathway can stimulate manifestation of autoimmune disorders such as experimental autoimmune encephalomyelitis [19], experimental autoimmune uveoretinitis [21], or spontaneous autoimmune diabetes [22]. The gene discussed is AHR; the disease is experimental autoimmune encephalomyelitis.