Neo-angiogenesis relies heavily in the HSP, mediated by classical angiogenic inducers such as VEGF and Angiopoietin-like factors and angiogenesis receptors (e.g., VEGFR, ANGPTR) and microenvironment matrix elements that act not only in the tumor cells themselves, but also in the tumor endothelial cells [15]. The gene discussed is KDR; the disease is neoplasm.