ESR1 and neoplasm: Having established that HER2 overexpression drives IL-1α-NF-κB-dependent CSC expansion and IL-1α-dependent tumor growth and lung metastasis, Liu et al. further demonstrated that the genetic loss of IL-1α in the HER2+/ERα−/PR− HCC1954 BCa cell line sensitizes the BCa cells to cisplatin or paclitaxel cytotoxicity [7].