NFKB1 and Familial prostate cancer: Although IL-1 levels were not assessed alongside NF-κB accumulation or activity in the studies above, we have found that RELA mediates IL-1 repression of Androgen Receptor (AR) hormone receptor expression in prostate cancer cells (PCa) [35] and, thus, NF-κB activity likely mediates IL-1 repression of ERα expression in BCa cells.