Bone-engrafted humanized mouse models injected orthotopically with MDA-MB-231 TNBC or IL-1β-overexpressing MDA-MB-231 cells and treated with anakinra or IL-1 neutralizing antibody, canakinumab, revealed that IL-1 enriches circulating tumor cells (CTCs) and bone metastasis [12,55]. The gene discussed is IL1B; the disease is neoplasm.