MAPK1 and retinopathy of prematurity: In addition to the substantial anti-angiogenic effect of miR-181a in ex vivo choroidal neovascularization and RNV in an in vivo mouse model of ROP, angiogenesis-related genes such as mitogen-activated protein kinase 1 (MAPK1), B-cell lymphoma 2 (Bcl2), and VEGF were downregulated in miR-181a-5p-overexpressed ECs [57,58,59].