MMP14 and fibrosarcoma: MMP-14 is a direct target gene of miR-181a-5p; essentially, miR-181a-5p-mediated reduction of MMP-14 was sufficient to reduce in vivo angiogenesis in chick chorioallantoic membrane assays and impair new blood vessel formation induced by HT1080 (a human fibrosarcoma cell line) [85].