HSPB1 and laryngeal squamous cell carcinoma: The prognostic value of the nuclear sublocalization of HSP27 was seldom described, except for one study performed by Kaigorodova EV et al. [31], who originally reported in laryngeal squamous cell carcinoma (LSCC), totaling 50 cases, that the nuclear expression of Hsp27, whether phosphorylated or unphosphorylated, was a molecular marker of an unfavorable prognosis.