HSPB1 and squamous cell carcinoma: In contrast, a flurry of research was conducted on other squamous cell carcinomas in reverse chronological order, including tongue [38], oral [39] and head and neck [40], all of which appeared to explicitly support the proposal that elevated HSP27 was heavily involved in chemoresistance of SCC, suggesting a possible causal relationship between elevated HSP27 and chemoresistance.