Further supporting this suggestion, direct evidence from an in vivo mouse model and an in vitro cell culture investigation made by Hadchity E et al. [49] demonstrated that silencing HSP27 with OGX-427, a second-generation antisense oligonucleotide, was able to sensitize radiosensitive HNSCC cells to radiation. The gene discussed is HSPB1; the disease is head and neck squamous cell carcinoma.