Attempting to further evaluate the prognostic value of HSP27 expression, Wang A et al. [17] examined the expression of HSP27 by immunohistochemistry in a total of 158 clinical specimens, including 15 cases of normal tongue mucosa, 31 cases of dysplastic lesions, 80 cases of TSCC and 32 lymph node metastases, demonstrating that lower Hsp27 expression was markedly correlated with worse overall survival. Here, HSPB1 is linked to metastatic malignant neoplasm in the lymph nodes.