In addition, another study from Zhang X and coworkers [6] in our laboratory made a similar observation that SUMOylated HSP27, once genetically inhibited by transfection with short hairpin RNA (shRNA) targeted to SUMOylation, can significantly suppress EMT in ESCC, explicitly indicative of its control of EMT. The gene discussed is HSPB1; the disease is esophageal squamous cell carcinoma.