The first report on the clinicopathological significance of HSP27 expression was from oral squamous cell carcinoma (OSCC) by Mese H et al. [19], reporting that no correlation was observed between HSP27 expression and the clinical stage, lymph node metastasis or histological grade of OSCC tissues, employing a total of 40 cases. This evidence concerns the gene HSPB1 and oral cavity squamous cell carcinoma.