HSPB1 and head and neck squamous cell carcinoma: Along the same line, in head and neck squamous cell carcinoma (HNSCC) and oral squamous cell carcinoma (OSCC), the expression status of HSP27 remains controversial, with some [9,10] reporting that HSP27 was up-regulated and others [11,12] reporting it was down-regulated in neoplastic tissues relative to normal controls.