HSPB1 and esophageal squamous cell carcinoma: In support of this, Miyazaki T et al. [27], enrolling 61 patients with ESCC before treatment with chemoradiotherapy (31 patients) or radiotherapy (30 patients) and investigated the potential association of HSP27 expression with chemo or radiotherapy, revealing that HSP27 was the most reliable predictor of the effect of chemoradiotherapy and radiotherapy by multivariate analyses.