While how exactly adipose tissue DCs, and, if so, which subsets, contribute to inflammation in obesity remains incompletely understood, a recent study suggests that adipose tissue CD11b+ CD103‒ DC expressed more IL-1β, IL-6, and IL-23 mRNA at the transcriptomic level and can affect Th17 maturation [36]. The gene discussed is ITGAE; the disease is obesity due to melanocortin 4 receptor deficiency.