TTR and amyloidosis: Hereditary TTR Amyloidosis is a systemic amyloid disease that is largely dictated by the presence of inherited autosomal dominant single nucleotide polymorphisms in the TTR gene—of which there are more than 100 known mutants [5]—and can present with multi-tissue etiologies including cardiomyopathy and peripheral neuropathies, as well as multi-organ system etiologies [3,4].