PDGFRA and coronary artery disorder: While inhibiting PDGF signaling pathways involved in fibrosis would likely be beneficial in the context of cardiac reactive fibrosis, it is less clear how this would affect the stability of the atherosclerotic plaqueA recent GWAS study identified PDGFRA, the gene encoding PDGFRα, as a CAD-associated gene, with high expression of PDGFRA in coronary arteries being associated with a higher risk of CAD [170].