In addition to being regarded as drivers of a tumor-promoting related anti-inflammation environment, macrophages directly bolster tumor progression by stimulating cancer stem cell proliferation via WNT signaling and promoting angiogenesis via production of VEGF, paving the way to tumor cell metastasis and invasion via remodeling of the extracellular matrix (ECM) and paracrine activities of epidermal growth factor (EGF) family ligands [13,30,31,32,33]. Here, EGF is linked to neoplasm.