The age of 9–12 months was chosen to serve as a positive control since it corresponds to (i) the mid-stage of AD-like pathology when virtually all transgenic mice express substantial amounts of cerebral amyloid [17] and (ii) the peak of glial activation when the chronic neuroinflammation is full-blown in the APP/PS1 model [20]. The gene discussed is APP; the disease is Alzheimer disease.