Notably, the increased TNFα expression in the hippocampus, the brain region involved in memory formation and among the most vulnerable to AD, coincides with “neuroinflammation-like” phenomena, comprising signs of glia activation in two different mouse models (TgCRND8 [5] and APPswePS1dE9 (APP/PS1) [7]). This evidence concerns the gene TNF and Alzheimer disease.