Therefore, it is still likely that RUNX3+EOMES+T-bet− cells are precursors of brain CD8+ TRM-populations in MS; however, their differentiation is likely to be controlled by other TRM-associated transcription factors, such as B lymphocyte-induced maturation protein-1 (BLIMP-1) [28]. Here, RUNX3 is linked to myeloid sarcoma.