This is consistent with our results that especially circulating RUNX3+EOMES+T-bet− cells but not RUNX3+EOMES−T-bet+ cells display a brain-homing and an MS brain residency-associated memory CD8+ T cell phenotype, as reflected by increased expression of CCR5 [4,24,25], CCR6 [26], CXCR3 [25], GZMK [2,4], CD20 [6] and CD69 [4,5], as well as their enrichment in MS CSF. This evidence concerns the gene CD8A and myeloid sarcoma.