Furthermore, miR-25 was identified as a miRNA repressed indirectly by P53 through the transcriptional regulators of the TP53 gene, E2F1 (also called retinoblastoma binding protein-3) and MYC; in this regard, there are experimental data only concerning the pathological state of glioblastoma [41]. This evidence concerns the gene E2F1 and glioblastoma.