HDAC2 and idiopathic pulmonary fibrosis: Moreover, it could be recently demonstrated that the AECII-specific conditional loss of Sin3a, a key component of the Sin3-HDAC1/HDAC2 corepressor complex, results in profound AECII senescence and spontaneous progressive lung fibrosis in mutant mice that closely resembles the pathological remodelling seen in IPF [120].