Similarly, Class IIA HDACs also promote tumorigenesis: HDAC4 promotes the growth of colon cancer cells or the progression of epithelial ovarian cancer via epigenetic CIP1/p21 repression by acting as a corepressor in a complex with HDAC3 [200,201] and mediates cisplatin resistance in various cancer cells through the dysregulation of autophagy and apoptosis pathways [202,203]. Here, CDKN1A is linked to colonic neoplasm.