Interestingly, a recent in vitro study showed that the weak pan-HDAC inhibitor 4-phenyl-butyrate (4-PBA) alleviated the aggregation and improved the secretion of IPF-associated mutant SP-A2 proteins in A549 cells through the upregulation of glucose-regulated protein (GRP)78 [255]. This evidence concerns the gene SFTPA2 and idiopathic pulmonary fibrosis.