Among the anti-fibrotic miRNAs downregulated in lung fibrosis, miR-26a was shown to inhibit myofibroblast differentiation and experimental lung fibrosis through its ability to downregulate the expression of its target CTGF [85], and forced expression of miR-9-5p was demonstrated to suppress FMD and lung fibrosis development through downregulating Nox4 and TGF-βRII [86]. The gene discussed is CCN2; the disease is pulmonary fibrosis.