Further, HDAC5 displays a significant upregulation in lung cancer and increases the proliferation and invasion of lung cancer cells through the upregulation of DLL4 (Delta-like protein 4), Notch-1 (Neurogenic locus notch homolog protein 1) and Twist-1 (Twist-related protein 1) [205]. The gene discussed is NOTCH1; the disease is lung carcinoma.