Moreover, a lack of CD4+ T cells in nephritic rats and mice [42,43] as well as the inhibition of the Th1 response by blocking IFNγ [47,48], IL-12 [60,61], or IL-18 [61] resulted in reduced glomerular macrophage accumulation, demonstrating that Th1 cells regulate renal macrophage infiltration and thus, kidney injury in cGN. The gene discussed is IFNG; the disease is childhood gender nonconformity.