We first analyzed Ide RNA levels in retinas from three RP mouse models carrying distinct mutations: rd1 (Pde6brd1/rd1) and rd10 (Pde6brd10/rd10) mice, which carry nonsense and missense mutations in the Pde6b gene, respectively, and the P23H/P23H (RhoP23H/P23H) mice, which harbor a Pro23His replacement in the rhodopsin gene. The gene discussed is RHO; the disease is retinitis pigmentosa 1.