All in all, due to the controversial discussion about GH supplementation and IGF1 levels, this Comment aimed to stimulate researchers to perform further studies on the pleiotropic effects of IGF1 on the oocyte, especially in women of advanced age and in those patients with GH/IGF1 deficiencies, including patients with diabetes mellitus or other metabolic disorders. The gene discussed is GH1; the disease is metabolic disease.