TASP1 and syndromic intellectual disability: Recently, loss-of-function variants of TASP1 were associated with a severe intellectual disability syndrome that resembles diseases, which are caused by defective histone-modifying methyltransferases [116], reflecting the general impact of TASP1 function on the activation of morphogenic factors like MLL, but also on the activity of methyltransferases as well as on general transcription factor (e.g., TFIIA) homeostasis [117,118].