CFB and age-related macular degeneration: Although its pathogenesis is still unclear, there is a proven genetic background, with polymorphisms within genes encoding complement factor H, human high-temperature requirement A-1 (HTRA1), age-related maculopathy susceptibility 2 (ARMS2), complement factor B (CFB), complement C2 and C3, identified as potential predictors for AMD development [4,5].