For the infection of endothelial cells, KSHV is presumed to bind to host cell surface receptors such as integrins α3β1, αVβ5 and αVβ3, the cystine-glutamate transporter xCT, heparan sulfate, and the tyrosine protein kinase receptor EPHA2 [16]. This evidence concerns the gene SLC7A11 and infection.