CAV1 and Kaposi's sarcoma: v-IL6, a protein expressed both during the latent (at lower but functional levels) and lytic viral phase of KSHV, plays an important role in KS genesis through angiogenesis, cell proliferation and invasion via downregulation of caveolin 1 (CAV1) [96], which has been shown to play an important role in survival, proliferation and migration of endothelial cells, as well as inhibiting pericyte and smooth muscle cell proliferation [97].