Vacuolating cytotoxin A (VacA) induces Ca2+ influx, production of reactive oxygen species (ROS), activation of the nuclear factor kappa light chain enhancer of B cell activation (NFκB), and increased expression of chemokines, presumably increasing the influx of pro-inflammatory immune system cells to the site of bacterial infection of H. pylori [50]. The gene discussed is NFKB1; the disease is bacterial infectious disease.