LINC-ROR rs1942347*A/A patients were more likely to have a positive family history of SLE, whereas HOTAIR rs10783618*C/C was associated with higher frequency of arthritis (p = 0.001) and the presence of oral ulcers (p = 0.002), while patients carrying HOTAIR rs10783618*T/T genotype were more likely to develop hair loss (p < 0.001), weight loss (p = 0.001), and neurological symptoms (p = 0.003). This evidence concerns the gene HOTAIR and Arthritis.