Heterozygotes of MALAT1 rs3200401*T/C were associated with a 49–57% decreased risk of SLE under codominant (OR = 0.51, 95%CI = 0.31–0.82, p < 0.001) and over-dominant models (OR = 0.43, 95%CI = 0.27–0.68, p < 0.001). The gene discussed is MALAT1; the disease is systemic lupus erythematosus.