In this preliminary study, based on our in silico analyses and searches of previous literature for some lncRNAs-related variants that have not been extensively explored in SLA [9,20,21,22], the following LncRNA variants were selected: (1) the lncRNA HOX transcript antisense RNA (HOTAIR) rs10783618, and (2) the intergenic lncRNA regulator of reprogramming (LINC-ROR) rs1942347, which have been associated with autoimmune diseases but no or little studies have been explored with SLE [23,24,25], as well as (3) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) rs3200401. Here, MALAT1 is linked to autoimmune disease.