Based on these findings, we attempted to analyze the role of eight synovial interleukins (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, and IL-17) in post-arthroplasty pain caused by various causes, including aseptic loosening, PJI, and acute onset of RA. The gene discussed is IL4; the disease is rheumatoid arthritis.