The BD group had higher peak levels of NSE than the non-BD group (170.6 [IQR, 91.2–210.0] ng/mL vs. 67.6 [IQR, 33.5–200.0] ng/mL, p = 0.011), and ROC analysis revealed that the peak level of NSE had an AUC for BD of 0.54 [95% CI, 0.38–0.69]. This evidence concerns the gene ENO2 and Behcet disease.