TP53 and cancer: Recent studies have pointed out that, in addition to controlling various cellular processes (e.g., apoptosis, cell cycle, senescence) in response to cellular stress to antagonized malignant progression [31], the TP53-mediated tumor suppression also involved activation of ferroptosis [32], remodeling cancer metabolism [33], inhibition of cellular self-renewal [34], ensuring genomic integrity [35], and maintenance a tumor-suppressive immune response [36].